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Our new paper is out! UBR5, a Novel E3 Ligase in Skeletal Muscle Hypertrophy & Atrophy

April 4, 2019|0 Comments

See our latest paper published as a Pre-Print in BioRxiv (click for PDF) where we show that UBR5 is a novel E3 Ubiquitin Ligase important for skeletal muscle hypertrophy & recovery from atrophy after disuse and injury. Also, that it has opposite roles to other well known E3 Ubiquitin Ligases, MuRF1 and MAFbx! We use several in-vivo and in-vitro approaches in human, animals, bioengineered models and cells at the genetic, DNA methylation, gene expression and protein level to characterise this newly identified ligase in the regulation of skeletal muscle mass. Check it out! PDF


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