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Publications (inc. Links & PDFs)

Major Peer Reviewed Articles (*Corresponding Author)

  • Seaborne RA, Strauss J, Cocks M, Shepherd S, O’Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples, AP*. Methylome of Human Skeletal Muscle after Acute & Chronic Resistance Exercise Training, Detraining & Retraining.Scientific Data (Nature), 5, Article number: 180213. [IF. 4.83]. PDF

 

  • Daniel C. Turner, Andreas M. Kasper, Robert A. Seaborne, Alexander D. Brown, Graeme L. Close, Mark Murphy, Claire E. Stewart, Neil RW. Martin and Sharples AP*. 2018. Exercising Bioengineered Skeletal Muscle In Vitro: Biopsy to Bioreactor. In: Rønning S. (eds) Myogenesis. Methods in Molecular Biology, vol 1889. Humana Press, New York, NY. Springer Nature LINK.

 

  • Seaborne RA, Strauss J, Cocks M, Shepherd S, O’Brien TD, van Someren KA, Bell PG, Murgatroyd C, Morton JP, Stewart CE, Sharples, AP*. 2018. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Scientific Reports (Nature), 8(1):1898. [IF. 4.609]. PDF

 

  • Impey S, Hammond K, Naughton R, Langan-Evans C, Shepherd S, Sharples AP, Cegielski J, Smith K, Jeromson S, Hamilton DL, Close GL, Morton JP. 2018. Whey protein augments leucinemia and post-exercise p70S6K1 activity compared to a hydrolysed collagen blend when in recovery from training with low carbohydrate availability. International Journal of Sport Nutrition & Exercise Metabolism, doi: 10.1123/ijsnem.2018-0054 [Epub ahead of print]. [IF. 2.49]. Link

 

  • Fisher A, Seaborne RA (Joint primary author) et al., Sharples AP* (joint corresponding author), Jarvis JC. 2017 Transcriptomic and Epigenetic Regulation of Skeletal Muscle Disuse Atrophy and Recovery. FASEB J, 31(12):5268-5282. [IF. 5.59]. Link

 

  • Sharples AP*, Seaborne RA, Stewart CE. 2017. Epigenetics of skeletal muscle aging. In: Epigenetics of Aging and Longevity, Editors; Moskalev A, Vaiserman A, Series Editor; Trygve O. Tollefsbol. Elsevier. (link).

 

  • Dugdale HF, Hughes DC, Allan R, Deane CS, Coxon CR, Morton JP, Stewart CE, Sharples, AP*. 2017. The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, 444(1-2):109-123. [IF. 2.56]. PDF

 

  • Brown AD, Close GC, Sharples AP, Stewart CE. 2017. Murine Myoblast Migration: Influence of Replicative Ageing and Nutrition. Biogerontology, 18(6):947-964. [IF. 3.702]. PDF

 

  • Allan R, Sharples AP, Close G, Drust B, Shepherd S, Fraser W, Morton JP, Gregson W. 2017. The acute cold-induced increase in PGC-1α is partially mediated systemically through increased β-adrenergic stimulation. Journal of Applied Physiology, 123(2), 451-459. [IF. 3.256]. PDF

 

  • Kasper A, Turner D, Martin NRW, Sharples AP*. Mimicking exercise in three-dimensional bioengineered skeletal muscle to investigate the cellular and molecular mechanisms of physiological adaptation. Journal of Cellular Physiology, 233(3):1985-1998. [IF. 4.08]. Link

 

  • Saini A, Sharples AP* (joint primary author), Al-Shanti N, Stewart CE. 2016. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology, 18(1), 109-129. [IF. 3.702]. PDF

 

  • Sharples AP*. 2017. Cellular and Molecular Exercise Physiology: A Historical Perspective for Discovery of Mechanisms Contributing to Skeletal Muscle Adaptation. Cellular and Molecular Exercise Physiology, 5(1), e10. PDF

 

  • Girven M, Dugdale HF, Owens D, Hughes DC, Stewart CE, Sharples AP*.L-glutamine improves skeletal muscle cell differentiation and prevents myotube atrophy after cytokine (TNF-α) stress via reduced p38 MAPK signal transduction. Journal of Cellular Physiology, 231(12), 2720-2732. [IF. 4.08].Link

 

  • Sharples AP*, Stewart CE, Seaborne RA. 2016. Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging Cell, 15(4), 603-16. [IF. 7.627]. Won most accessed article in 2016. PDF

 

  • Hammond KM, Impey SG, Currell K, Mitchell N, Shepherd SO, Jeromson S, Hawley JA, Close GL, Hamilton DL, Sharples AP, Morton JP. 2016. Post exercise high-fat feeding supresses p70S6K1 activity in human skeletal muscle. Medicine and Science in Sports and Exercise, 48(11), 2108-2117. [IF. 4.141].Link

 

  • Impey SG, Hammond KM, Shepherd SO, Sharples AP, Stewart C, Limb M, Smith K, Philp A, Jeromson S, Hamilton DL, Close GL, Morton JP. 2016. Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes. Physiological Reports, 4(10), pii: e12803. PDF

 

  • Hughes DC, Yousefian F, Sculthorpe N, Stewart CE, Lewis MP, Sharples AP*.Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors. Biogerontology, 17(3), 619-39. [IF. 3.702].PDF

 

  • Sharples AP*, Polydorou I, Hughes DC, Owens DJ, Hughes TM, Stewart CE. 2015. Skeletal muscle cells possess a memory of acute early life TNF-α exposure: Role of epigenetic adaptation. Biogerontology, 17(3), 603-17. [IF. 3.702]. Link

 

  • Owens DJ, Sharples AP, Polydorou I, Alwan N, Donovan T, Tang J, Fraser WD, Morton JP, Stewart CE, Close GL. 2015. A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy. American Journal of Physiology- Endocrinology and Metabolism, 309(12), E1019-31. [IF. 4.018]. PDF

 

  • Sharples AP* and Stewart CE. 2015. Comments on the CrossTalk proposal and opposing view: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis/proteolysis. Journal of Physiology. 592(24), 5341–5343. [IF. 5.037]. PDF

 

  • Sharples AP*, Hughes DC, Deane CD, Saini A, Selman C, Stewart CE. 2015. Longevity and Skeletal Muscle Mass: The role of IGF signalling, the Sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), 511-23. [IF. 7.627]. Won most accessed article in 2015. PDF

 

  • Player DJ, Martin NRW, Passey SL, Sharples AP, Mudera V, Lewis MP. 2014. Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle. Biotechnology Letters, 36(5), 1113-1124. [IF. 1.846]. Link

 

  • Deane CD, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP*. 2013. Impaired hypertrophy in myoblasts is improved with testosterone administration. The Journal of Steroid Biochemistry and Molecular Biology, vol. 138, 152-161. [IF. 4.095]. Link

 

  • Martin NRW, Passey SL, Player DJ, Khodabukus A, Ferguson RA, Sharples AP, Mudera V, Baar K, Lewis MP. 2013. Factors affecting the structure and maturation of human tissue engineered skeletal muscle. Biomaterials, 34(23), 5759-5765. [IF. 8.806]. Link

 

  • Sharples AP*, Al-Shanti N, Hughes DC, Lewis MP, Stewart CE. 2013. The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy. Growth Hormone and IGF Research, 23(3), 53-61. [IF. 2.369]. Link

 

  • Sharples AP*, Player DJ, Martin NR, Mudera V, Stewart CE, Lewis MP. 2012. Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. Aging Cell, 11(6), 986-995. [IF. 7.627]. PDF

 

  • Saini A, Al-Shanti N, Sharples AP, Stewart CE. 2012. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Experimental Physiology, 97(3), 400-418.[IF. 2.912]. PDF

 

  • Sharples AP* and Stewart CE. 2011. Myoblast models of skeletal muscle hypertrophy and atrophy. Current Opinion in Clinical Nutrition and Metabolic Care, 14(3), 230-236. [IF. 4.534]. Link

 

  • Sharples AP*, Al-Shanti N, Lewis MP, Stewart CE. 2011. Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: a model to investigate ageing? Journal of Cellular Biochemistry, 112(12), 3773-3785.[IF. 3.085]. Link

 

  • Sharples AP*, Al-Shanti N, Stewart CE. 2010. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? Journal of Cellular Physiology, 225(1), 240-250. [IF. 4.08]. Link

 

  • Tolfrey K, Doggett A, Boyd C, Pinner S, Sharples A, Barrett L. 2008. Postprandial triacylglycerol in adolescent boys: a case for moderate exercise. Medicine and Science in Sports and Exercise, 6(40), 1049-1056. [IF. 4.141].Link

 

Book Chapters:

 

  • Sharples AP*, Seaborne RA, Stewart CE. 2017. Epigenetics of skeletal muscle aging. In: Epigenetics of Aging and Longevity, Editors; Moskalev A, Vaiserman A, Series Editor; Trygve O. Tollefsbol. Elsevier. (link).

 

  • Hughes D, Sculthorpe N, Sharples AP and Lewis M. 2012. Testosterone and molecular regulation of skeletal muscle. In: Perspectives on Anabolic Androgenic Steroids (AAS) and Doping in Sport and Health. Nova publishers: ISBN: 978-1-62081-243-3.

 

 

Other Publications

 

  • Acknowledged in: Allan R, Mawhinney CR. 2016. Is the ice bath finally melting? CWI is no greater than active recovery upon local and systemic inflammatory cellular stress in humans. Journal of Physiology. 595(6):1857-1858.

 

Peer Reviewed Conference Publications

 

  • Turner DC, Seaborne RA, StewartCE, MurphyMF, JarvisJC, MartinNRW, Sharples AP*. Mechanical loading of murine bioengineered skeletal muscle mimics the transcriptional and epigenetic response of human skeletal muscle after exercise. European Cells and Materials, TCES 2018, Staffordshire, UK.

 

  • Maasar MF, Hulton AT, Sharples AP, Drust B. A comparison of the physiological responses to a different number of changes of direction: 5, 10 and 15m shuttle runs. European College of Sport Science (ECSS),Dublin, UK. Submitted.

 

  • Brown A, Close GC, Sharples AP, Stewart CE. 2017. Mechanisms underpinning enhanced migration capabilities of replicatively aged C2C12 myoblasts. British Society for Research on Ageing (BSRA), Exeter, UK.

 

  • Hammond KM, Impey SG, Currell K, Mitchell N, Shepherd SO, Jeromson S, Hawley JA, Close GL, Hamilton DL, Sharples AP, Morton JP. 2016. Post exercise high-fat feeding supresses p70S6K1 activity in human skeletal muscle. European College of Sport Science (ECSS), Vienna, Austria. [Student awarded 2nd prize oral presentation].

 

  • Allan R, Sharples AP, Close G, Drust B, Shepherd S, Fraser W, Morton JP, Gregson W. 2016. The acute cold-induced increase in PGC-1α is partially mediated systemically through increased β-adrenergic stimulation. European College of Sport Science (ECSS),Vienna, Austria.

 

  • Owens DJ, Sharples AP, Donovan T, Tang J, Fraser WD, Morton JP, Stewart CE, Close GL. 2016. Vitamin D and Skeletal Muscle Regeneration: A Systems Approach.Japanese Journal of Physical Fitness and Sports Medicine, 65, 157-157.

 

  • Dugdale HF, Stewart CE, Sharples AP*. 2016. Resveratrol enables myotube survival under nutrient stress. European Muscle Conference, Montpellier, France.

 

  • Wong FY, Morris S, Sharples AP, Low DA, Scott MA, Doran DA. 2015. Wong FY. Nucleotide supplementation does not improve repeated sprint performance. Journal of Sport Sciences, 33, Supplement 1, s5–s8.

 

  • Sharples AP*, Polydorou J, Hughes DC, Hughes TM, Stewart CE. 2015. Skeletal muscle myoblasts have a ‘memory’ of previous TNF-α insults: Role of DNA methylation. Proceedings of the Physiological Society, 33, PC23.

 

  • Dugdale HF, Stewart CE, Sharples AP*. The role of SIRT1 in aged and glucose restricted skeletal muscle cells. Proceedings of the Physiological Society, vol 33, PC25.

 

  • Owens DJ, Polydorou I, Alwan N, Fraser WD, Tang J, Morton J, Sharples AP, Stewart CE & Close GL. 2015. The Role of Vitamin D in Skeletal Muscle Repair: A Systems Biology Approach. European College of Sport Science (ECSS),Malmo, Sweden. [Student awarded ECR prize].

 

  • Wong FY, Morris S, Sharples AP, Low DA, Scott MA, Doran DA. 2015. Effect of 30 days oral purine and pyrimidine nucleotide supplementation upon repeated sprint ability performance. The British Association of Sport & Exercise Sciences, Liverpool, UK.

 

  • Hughes DC, Yousefian F, Sculthorpe N, Stewart CE, Lewis MP, Sharples AP*. 2014. Testosterone restores an aged myoblast phenotype via increases in AR and Akt Phosphorylation independently of upstream IGF-IR inhibition. British Society for Research on Ageing (BSRA), Liverpool, UK.

 

  • Dugdale HF, Stewart CE, Sharples AP*. 2014. The role of SIRTUIN1 in aged and calorie restricted skeletal muscle cells.British Society for Research on Ageing (BSRA), Liverpool, UK.

 

  • Sharples AP*, Hughes DC, Hughes TM, Stewart CE. 2013. Skeletal muscle myoblasts have a memory of previous TNF-α insults: Role of DNA methylation. EMBO conference: Molecular Mechanisms of Muscle Growth and Wasting in Health and Disease. Monte Verità, Ascona, Switzerland.

 

  • Potter C, Hughes D, Sharples A, Davies B, Dixon N, Tuttle J, Mauger A, Castle P, Christmas B, McNaughton L. 2013. Combined Effect of Hyperhydration And Pre-Cooling on Endurance Cycling Performance in Hot and Humid Conditions. Medicine and Science in Sports and Exercise, 5S, pp. 61-71.

 

  • Sharples AP*, Al-Shanti N, Stewart CE. 2012. Tumour Necrosis Factor- Alpha (TNF-α) increases susceptibility to inhibition of differentiation in artificially aged muscle stem cells. British Society for Cell Biology (BSCB), Warwick, UK.

 

  • Sharples AP*, Player DJ, Martin NRW, Stewart CE, Lewis MP. 2012. Mechanical Stretching of Artificially Aged Myoblasts in Physiologically Relevant 3-Dimensional Bioengineered constructs. European College of Sport Science (ECSS). Bruge, Belgium.

 

  • Hughes DC, Sculthorpe N, Sharples AP, Lewis MP. 2012. The effects of testosterone on molecular markers of hypertrophy in C2C12 skeletal muscle cells. Proceedings of the Physiological Society, 26, PC61.

 

  • Deane CS, Hughes, DC, Sculthorpe, N. & Sharples AP*. Testosterone rescues differentiation and hypertrophy in artificially aged skeletal muscle myoblasts. 8th International Conference on Strength Training, October 24th – 28th, Oslo, Norway.

 

  • Sharples AP*, Player DJ, Martin NRW, Passey S, Stewart CE, Lewis MP. 2011. Replicative ageing of myoblasts in 3-D tissue engineered collagen constructs. European Cells and Materials, 22(1), 48-53. [IF. 4.89].

 

  • Player DJ, Martin NRW, Castle PC, Passey S, Sharples AP, Lewis MP. Mechanical stimulation of 3D bio-engineered skeletal muscle. European Cells and Materials, 22(1), 38-48. [IF. 4.89].

 

  • Player DJ, Martin NRW, Castle PC, Sharples AP, Passey S, Mudera V, Lewis MP. 2011. A putative model of endurance exercise using bio-engineered skeletal muscle. Proceedings of the Physiological Society, vol. 23, PC333.

 

  • Sharples AP*, Player DJ, Martin NRM, Passey S, Stewart CE, Lewis MP. 2011. Artificially aged skeletal myoblasts display reduced regeneration in bio-engineered skeletal muscle. Proceedings of the Physiological Society, vol. 23, PC327.

 

  • Sharples AP*, Al-Shanti N, Stewart CE. 2010. Differential responses of C2 and C2C12 mouse skeletal myoblasts in the absence or presence of tumour necrosis factor- alpha (TNF-α). Society for Endocrinology. Manchester, UK. Endocrine Abstracts, vol. 21, P127.