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Our latest Epigenetics paper has been posted as a Pre-Print!

12th November 2018|0 Comments

We have just released our latest article as a pre-print in Bioarxiv (PDF) while it is currently under review with Scientific Reports. This work undertakes large scale bioinformatical analysis by pooling the publicly available transcriptome data after acute and chronic resistance exercise in human skeletal muscle and comparing these large data sets with our genome-wide DNA methylation analysis in human skeletal muscle after acute and chronic resistance exercise, detraining and retraining.

The data suggests that there are extensive DNA methylation alterations with corresponding gene expression changes predominantly associated with pathways such as extracellular matrix / actin structure and remodelling, mechano-transduction and TGF-Beta signalling after both acute and chronic resistance exercise. Furthermore, that some of these genes, notably Filamin B, are remaining differentially methylated even when detraining occurs after a period of exercise induced hypertrophy, highlighting these as newly identified epigenetically regulated memory genes!

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