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  • New paper – DNA methylation across the genome in aged human skeletal muscle tissue and muscle stem cells - See our pre-print demonstrating the #HOXGenes in Aged #MuscleStemCells (MuSCs) and Skeletal Muscle Tissue have altered #DNAmethylation when compared to young muscle. High #PhysicalActivity in young adults was associated with an opposite regulation of DNA methylation in the HOX genes compared with aged muscle. Suggesting increasing physical activity could perhaps reverse the age-related DNA methylation in HOX genes #epigenetic #aging #preprint See link to the […]
  • Our Labs New book Chapter - Exercise and DNA methylation in skeletal muscle (Sept 2019) Click the Link for the chapter PDF
  • Our UBR5 paper published in full: The Journal of Physiology - Our latest paper has been accepted and is now online in The Journal of Physiology! Click here for the paper! Key points for the paper include: We have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle hypertrophy, where its gene expression is […]
  • Our new paper is out! UBR5, a Novel E3 Ligase in Skeletal Muscle Hypertrophy & Atrophy - See our latest paper published as a Pre-Print in BioRxiv (click for PDF) where we show that UBR5 is a novel E3 Ubiquitin Ligase important for skeletal muscle hypertrophy & recovery from atrophy after disuse and injury. Also, that it has opposite roles to other well known E3 Ubiquitin Ligases, MuRF1 and MAFbx! We use several […]
  • Comparative transcriptome and epigenome paper published in full! - Our latest paper is out! @SciReports (PDF). Using ‘big data’ (bioinformatical) analysis we identify genes that are both epigenetically altered as well as turned on/off across the entire genome after acute exercise, muscle growth, detraining & retraining. Great work authors @dcturner93 & @RobbySeaborne In this new @SciReports paper (PDF), we identify epigenetically altered pathways in muscle hypertrophy that include […]